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Induced Pluripotent Stem Cells 11.5

The Induced Pluripotent Stem Cell (IPSC) Distribution v11.5 was published on 2024-12-09. IPSC Distribution v11.5 includes 1306 subjects, 1272 of whom have at least one biosample on record at the repository. There are 565 IPSCs, 626 FCLs, and 8 OEs as of the release. In addition to case/control studies, the IPSC collection includes 10 family studies.

Standard Data & Documentation

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Distribution Bundle [text or excel]: Standard files across disorders, containing demographic, diagnostic, and pedigree information. Sampled (formerly IBX) sample IDs (nrgr_bio_id) and consent level are also provided. Bundle includes data dictionaries.
Study Descriptions.
Change Notes.
Pedigree Drawings.

Additional Data Files

Study 92 Family-Based Genome-Wide Methylation Scan in Neurocognition and Schizophrenia 130

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 101 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder 181

Clinical Instruments

iPSC Submitter Form

Study 101 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 115 Exploring the Neuronal Phenotype of Autism Spectrum Disorders Using iPSCs 20

Clinical Instruments

iPSC Submitter Form

Study 115 Singec iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Other

Phenotypic Data [text or excel] Includes demographics, diagnoses, body measurements, brain scan data, and summary data from ADI-R, ADOS, Mullen, SRS instruments. Additional subjects for study 115 can be found in the Phelan-McDermid Syndrome (PMS) collection.

Study 116 Cellular and Genetic Correlates of Increased Head Size in Autism Spectrum Disorder Autism Spectrum Disorder 38

Clinical Instruments

iPSC Submitter Form

Study 116 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Other

Phenotypic Data [text or excel] Includes item-level data for ADI, ADOS, DAS, Mullen, Vineland, and WISC instruments, along with NDA linking IDs.

Study 117 Autism iPSCs for Studying Function and Dysfunction in Human Neural Development 4

Clinical Instruments

Other

Phenotypic Data [text or excel] Includes demographics, diagnosis, and summary data from ADI, ADOS, and Stanford-Binet

Study 125 Analysis of Glutamatergic Neurons Derived from Patient Specific iPS Cells 13

Clinical Instruments

iPSC Submitter Form

Study 125 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Other

Study 125 Cdf Phen [text or excel] Data from IBX Cell Deposit Form

Study 127 Target Identification and Validation for Negative Symptoms and Social Cognition in Schizophrenia: A Translational Study 8

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 130 Genomics-Guided Characterization of iPS Cells from Common Mental Illnesses 4

Clinical Instruments

iPSC Submitter Form

Study 130 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Other

Study 130 Cdf Phen [text or excel] Data from IBX Cell Deposit Form

Study 131 Chemical genomic approaches to neurobiology of DISC1 20

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 132 NIMH DIRP Protocol 03-M-0035 Screening, Evaluation, Diagnosis, Treatment Optimization and Follow-Up for Childhood Onset Psychiatric Disorders 228

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 136 Integrative Molecular and Phenotype Analysis of 22q11.2 Deletion Syndrome 66

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 143 Modeling Anorexia Nervosa with Human Pluripotent Stem Cells 8

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 144 Modeling Autism with Human Pluripotent Cells 17

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 146 Induced Neuronal Cells: A Novel Approach to Study Neuropsychiatric Diseases 9

Clinical Instruments

iPSC Submitter Form

Study 146 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Other

Study 146 Cdf Phen [text or excel] Data from IBX Cell Deposit Form

Study 158 Modeling schizophrenia using iPSC neurons 11

Clinical Instruments

Other

Phenotypic Data [text or excel] Includes summary data for family history and diagnoses.

Study 159 A chimeric brain model to study human neurological diseases 7

Clinical Instruments

iPSC Submitter Form

Study 159 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Other

Study 159 Cdf Phen [text or excel] Data from IBX Cell Deposit Form

Study 160 Contrasting causal microRNAs in forebrain and midbrain COS hiPSC neural cells 11

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 163 Neuropsychiatric Genome-Scale and RDoC Individualized Domains (N-GRID) 134

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 165 Neural development of human induced pluripotent stem cells from schizophrenia patients 4

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 166 Juvenile Onset Schizophrenia iPSCs 14

Clinical Instruments

iPSC Submitter Form

Study 166 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Other

Study 166 Phenotypic Data [text or excel] s166-misc-phen (n=8) includes medications at time of biopsy and Children’s Global Assessment Score.
Study 166 Cdf Phen [text or excel] Data from IBX Cell Deposit Form

Study 175 Neurobiology of Autism With Macrocephaly 33

Clinical Instruments

iPSC Submitter Form

Study 175 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 182 Systematic Functional Interpretation of Regulatory Variants in Schizophrenia

Clinical Instruments

iPSC Submitter Form

Study 182 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 184 iPSC-based platform development for major psychiatric disorder modeling and discovery 17

Clinical Instruments

iPSC Submitter Form

Study 184 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 200 Mechanisms of Circuit Failure and Treatments in Patient-derived Neurons in Autism 15

Clinical Instruments

Other

Study 200 Phenotypic Data [text or excel] (n=17) includes autism and developmental assessment summary score data.

Study 201 Cellular, molecular, and functional imaging approaches to understanding early neurodevelopment in autism. Project 3: Biological substrates of risk and resilience using patient-derived stem cells 33

Clinical Instruments

iPSC Submitter Form

Study 201 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 101 — Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder

Study 101 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 115 — Exploring the Neuronal Phenotype of Autism Spectrum Disorders Using iPSCs

Study 115 Singec iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 116 — Cellular and Genetic Correlates of Increased Head Size in Autism Spectrum Disorder Autism Spectrum Disorder

Study 116 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 125 — Analysis of Glutamatergic Neurons Derived from Patient Specific iPS Cells

Study 125 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 130 — Genomics-Guided Characterization of iPS Cells from Common Mental Illnesses

Study 130 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 146 — Induced Neuronal Cells: A Novel Approach to Study Neuropsychiatric Diseases

Study 146 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 159 — A chimeric brain model to study human neurological diseases

Study 159 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 166 — Juvenile Onset Schizophrenia iPSCs

Study 166 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 175 — Neurobiology of Autism With Macrocephaly

Study 175 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 182 — Systematic Functional Interpretation of Regulatory Variants in Schizophrenia

Study 182 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 184 — iPSC-based platform development for major psychiatric disorder modeling and discovery

Study 184 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 201 — Cellular, molecular, and functional imaging approaches to understanding early neurodevelopment in autism. Project 3: Biological substrates of risk and resilience using patient-derived stem cells

Study 201 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.

Study 115 — Exploring the Neuronal Phenotype of Autism Spectrum Disorders Using iPSCs

Phenotypic Data [text or excel] Includes demographics, diagnoses, body measurements, brain scan data, and summary data from ADI-R, ADOS, Mullen, SRS instruments. Additional subjects for study 115 can be found in the Phelan-McDermid Syndrome (PMS) collection.

Study 116 — Cellular and Genetic Correlates of Increased Head Size in Autism Spectrum Disorder Autism Spectrum Disorder

Phenotypic Data [text or excel] Includes item-level data for ADI, ADOS, DAS, Mullen, Vineland, and WISC instruments, along with NDA linking IDs.

Study 117 — Autism iPSCs for Studying Function and Dysfunction in Human Neural Development

Phenotypic Data [text or excel] Includes demographics, diagnosis, and summary data from ADI, ADOS, and Stanford-Binet

Study 125 — Analysis of Glutamatergic Neurons Derived from Patient Specific iPS Cells

Study 125 Cdf Phen [text or excel] Data from IBX Cell Deposit Form

Study 130 — Genomics-Guided Characterization of iPS Cells from Common Mental Illnesses

Study 130 Cdf Phen [text or excel] Data from IBX Cell Deposit Form

Study 146 — Induced Neuronal Cells: A Novel Approach to Study Neuropsychiatric Diseases

Study 146 Cdf Phen [text or excel] Data from IBX Cell Deposit Form

Study 158 — Modeling schizophrenia using iPSC neurons

Phenotypic Data [text or excel] Includes summary data for family history and diagnoses.

Study 159 — A chimeric brain model to study human neurological diseases

Study 159 Cdf Phen [text or excel] Data from IBX Cell Deposit Form

Study 166 — Juvenile Onset Schizophrenia iPSCs

Study 166 Phenotypic Data [text or excel] s166-misc-phen (n=8) includes medications at time of biopsy and Children’s Global Assessment Score.
Study 166 Cdf Phen [text or excel] Data from IBX Cell Deposit Form

Study 200 — Mechanisms of Circuit Failure and Treatments in Patient-derived Neurons in Autism

Study 200 Phenotypic Data [text or excel] (n=17) includes autism and developmental assessment summary score data.