The NIMH Center for Collaborative Genomic Studies on Mental Disorders was established through the NIMH Human Genetics Initiative in 1998 to leverage and increase the value of human genetic samples and data produced through NIMH funded research.

The NIMH Center, now known as NIMH Repository and Genomics Resource (NIMH-RGR) plays a key role in facilitating psychiatric genetic research by providing a collection of over 150,000 well characterized, high quality patient and control samples from a wide-range of mental disorders. Through concerted and collaborative efforts of the Biologic Core (Rutgers University’s RUCDR Infinite Biologics) and Data Management Core (Washington University in St. Louis and the University of Southern California's Information Sciences Institute), the Center provides the following services:

  • Receive, process and store biomaterials ready for analysis (DNA, cell lines and other products) from various primary sources (e.g., blood or skin biopsy) submitted by NIMH grantees
  • Distribute biomaterials to approved investigators (access biosamples)
  • Receive, process and distribute clinical and genetic data to approved investigators (access data)
  • Create and distribute computational tools and sample selection tools that support analysis of the genomic and clinical data.

The NIMH Stem Cell Resource (at RUCDR), a component of NIMH-RGR, provides banking and validation of reprogrammed cells (e.g., iPSCs) and source cells (e.g., fibroblasts) derived from postnatal-to-adult human patients and controls.

The Center is funded by a cooperative agreement, U24MH068457, from the National Institute of Mental Health.

What's New
Jun
12
2017
iPSC Dist. 8.0 includes data from Study 131 (PIs: Tsai, Cohen, Perlis).
May
22
2017
SZ Dataset 34 genotype data released (Study 9) in Schizophrenia Dist. 17.2.
May
10
2017
SZ Dataset 33 genotype data released (Study 90, Ireland study) in Schizophrenia Dist. 17.2.
Apr
26
2017
SZ Dist. 17.2 adds new data from Study 91 (PI: Goldstein).
Apr
18
2017
BP Dataset 31 genotype data released (Study 71) in Bipolar Disorder Dist. 11.3.
Apr
05
2017
RDoC Dist. 1.0 includes data from Study 120 (Tennessee Twin Study; PIs: Zald, Lahey).
Mar
08
2017
Depression Dist. 6.0 includes data from Study 83 (IRL GREY; PIs: Reynolds, Lenze, Mulsant).
Mar
08
2017
iPSC Dist. 7.0 includes data from Study 130 (PIs: Haggarty, Perlis) and Study 163 (PIs: Kohane, Perlis).
Publications

Mariani J, Coppola G, Zhang P, Abyzov A, Provini L, Tomasini L, Amenduni M, Szekely A, Palejev D, Wilson M, Gerstein M, Grigorenko EL, Chawarska K, Pelphrey KA, Howe JR, Vaccarino FM. FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders. Cell 2015 Jul 16; 162(2):375-390. PMID: 26186191

Governance
The NIMH Center for Collaborative Genomic Studies on Mental Disorders is supported by cooperative agreement U24 MH068457 from the NIMH.