Download Data
Bipolar Disorder
Bipolar Disorder 12.5
The Bipolar Disorder (BP) Distribution v12.5 was published on 2024-12-09. BP Distribution v12.5 includes 26781 subjects, 20079 of whom have at least one biosample on record at the repository. In addition to case control studies, the BP collection includes 10 family studies, one or more of which include families that are large and/or multigenerational.
Standard Data & Documentation
Download All- Distribution Bundle [text or excel]: Standard files across disorders, containing demographic, diagnostic, and pedigree information. Sampled (formerly IBX) sample IDs (nrgr_bio_id) and consent level are also provided. Bundle includes data dictionaries.
- Study Descriptions.
- Change Notes.
- Pedigree Drawings.
Additional Data Files
Genetic Data
Full Genome Genotyping
- BP Dataset 32 For more information, visit the CAPS homepage.
- BP Dataset 32 - readme For more information, visit the CAPS homepage.
Genetic Data
Full Genome Genotyping
- PGC-BP - data & documentation Introduction, results, plots, and genotype data. For more information about PGC, visit https://www.med.unc.edu/pgc.
- PGC-BP - imputation & dosage data Imputation & dosage data, separated due to file size (15.5 GB).
- PGC-BP - imputation & dosage data - ReadMe Case-control data on 7274 subjects. 7 cohorts available, some at NRGR. 3,803 Total Cases. Imputed Genotypes on 2.5M SNPs
Clinical Instruments
DIGS
Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.
File B: This file includes DIGS info for all other sites in BP distribution 4.0. Data may be in DIGS version 1.0 or 2.0, but both versions have a core of variables in common.
Genetic Data
Targeted Genotyping
- BP Dataset 22 Trace amine-associated receptor genes association study (TRAR), 36 markers. 1,476 subjects.
- BP Dataset 24 Clock and circadian rhythm genes association study, 2 sets. 1,432 subjects in set 1, 1,243 subjects in set 2.
- BP Dataset 26 PDLIM5 family-based association study. 5 markers, 1,938 subjects.
Genetic Data
Targeted Genotyping
- BP Dataset 17 genotypes from Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. 1,244 subjects.
Genetic Data
Full Genome Genotyping
- BP Dataset 27 Custom Illumina iSelect chip containing 7,584 SNPs on Chromosomes 1-22, 214 subjects.
Genetic Data
Full Genome Genotyping
- BP Dataset 16.01 STEP-BD data. Case-control. 2453 samples (955 cases). PLINK files available from Affymetrix 5.0 platform. Study 29 controls included in dataset.
- BP Dataset 28 720 markers on chromosomes 1-23. Controls from study 29. 832 subjects.
Genetic Data
Full Genome Genotyping
- BP Dataset 11 Case-Control data on 1956 samples. PLINK, logR/BAF files from Illumina 550k platform available. Intensity files are shipped by request due to the large size of the files. To request shipment, please contact help@nrgr.on.spiceworks.com and reference your active access approval ID.
Genetic Data
Full Genome Genotyping
- BP Dataset 20 Full Genome Screen. 624 markers, 238 subjects in 48 families
- BP Dataset 4 Full Genome Screen. 4,332 subjects.
Targeted Genotyping
- BP Dataset 1 36 markers (4 on chromosome 13, 4 on chromosome 18, 3 on chromosome 21, 15 on chromosome 22, 6 on chromosome 4, and 4 on chromosome 5). 355 subjects.
- BP Dataset 13 Chromosome 5q31-34 / psychosis, GRIA1, 330 subjects.
- BP Dataset 14 240 markers on Chromosomes 1-6, 8-13, 22, X, Y. 427 subjects.
- BP Dataset 15 20 ANK3 markers on chromosomes 1-7, 10-13, 17. 2,519 subjects.
- BP Dataset 2 10 Markers on Chromosome 22. 487 subjects.
- BP Dataset 23 19 Cholinergic genes (93 SNPs) on 707 subjects. Includes family data
- BP Dataset 25 1,005 neurotransmitter markers (GRIA1, GRIN2D, QDPR, GRIN2C, QDPR, slc6a3). 1,195 subjects.
- BP Dataset 3 K274E Mutation in PAH, 11 subjects.
- BP Dataset 5 233 markers on Chromosomes 6, 12, 13, 18, 22. 2,127 subjects.
- BP Dataset 7 62 SNPs on Chromosomes 3, 4, 11, 12, 18, 19, 22 - circadian rhythm pathways. 832 subjects.
- BP Dataset 8 19 SNPs on Chromosomes 1, 2, 11, 12, 17 - circadian rhythm pathways. 1,435 subjects.
- BP Dataset 9 93 SNPs on Chromosomes 1, 2, 4, 7, 8, 10, 11, 15, 17, 20 - cholinergic pathways. 401 subjects.
Clinical Instruments
BEFD
Genetic Data
Targeted Genotyping
- BP Dataset 10 1004 SNPs on Chromosomes 1-13, 15-17, 19-23 family-based association study of neurotransmitter pathways, 735 subjects.
- BP Dataset 6 30 trace amine receptors markers, 987 subjects
Clinical Instruments
BEFD
DIGS
Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.
File A: This file is in the DIGS version 3 paradox file format for distribution 4.01 data. It includes data for a group of 9 sites (from study1, wave3 & 4). These files are totally different in format from earlier versions (variable names, etc). This is DIGS 3.0/B.
Other
Genetic Data
Targeted Genotyping
- BP Dataset 12 P14K2b on Chromosome 4 / CERK, SULT4, BRD1, all genes on Chromosome 22, 248 subjects
Clinical Instruments
BEFD
Other
Clinical Instruments
BEFD
DIGS
Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.
File C: This file includes DIGS information for subjects in Study 8 added in BP Distribution 4.0. Data is in DIGS Version 2.0. Key variables are the same as in File B, but formats and variable lengths differ.
Other
Clinical Instruments
BEFD
Clinical Trial
Other
- Overview of STEP-BD Longitudinal clinical trial of outpatient BP cases.
- Study 19 Extended Diagnosis File [text or excel]
- Study 19 Age Onset Range Phen [text or excel]
Clinical Instruments
BEFD
DIGS
Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.
File D: This file includes DIGS information for subjects in Study 40 added in BP Distribution 6.02. This is a new version of DIGS.
Other
Study 48
Genetic Linkage and Association in Bipolar Disorder / Amish Mennonite Bipolar Genetics Study (AmBiGen)
471
Clinical Instruments
DIGS
Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.
DIGS data for Study 48 (Part 1)/Sites 186-188 (PIs: McMahon, DePaulo, Gershon) were collected using DIGS Version 3.0
Other
Genetic Data
Full Genome Genotyping
- BP Dataset 29 SNP Linkage Genotyping Data, 5,606 markers, 2,466 subjects.
Clinical Instruments
DIGS
Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.
File E: This file includes DIGS information for subjects in Study 49 Version 2 added in BP Distribution 7.01. This is DIGS Version 2.0.
Other
Clinical Instruments
Other
- Phenotypic Data Interview data includes Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS), Children's Global Assessment Scale (C-GAS), Home Environment Interview for Children (HEIC)
- Study 55 Extended Diagnosis File [text or excel]
Genetic Data
Full Genome Genotyping
- BP Dataset 31 Full Genome Screen, 1,054,197 SNPs, 838 subjects
Clinical Instruments
Other
- Phenotypic Data Data includes MRI results, and Temperament Evaluation of Memphis, Pisa, Paris, and San Diego (TEMPS), Weschler Abbreviated Scale of Intelligence (WASI), California Verbal Learning Test (CVLT), among other interviews.
- Study 71 Extended Diagnosis File [text or excel]
- Study 71 Dx Confidence Harmonization Phen [text or excel]
Clinical Instruments
Other
- Phenotypic Data LiTMUS - primary outcome measures include Clinical Global Impression Scale for Bipolar Disorder Severity (CGI-BP-S) and medical adjustments per month. MINI-PLUS used to dermine DSM-IV diagnoses.
Clinical Instruments
DI-PAD
- Phenotypic Data Diagnoses were reached using the OPCRIT system populated with DI-PAD data and supplemented by manual review of DI-PAD data as necessary.
Other
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
Clinical Instruments
Clinical Trial
- Phenotypic Data Diagnostic data, including Hamilton Depression Rating Scale, and response to Interpersonal and Social Rhythm therapy.
Other
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
MULTIPLE — Studies BP0, 1
- BP Dataset 22 Trace amine-associated receptor genes association study (TRAR), 36 markers. 1,476 subjects.
- BP Dataset 24 Clock and circadian rhythm genes association study, 2 sets. 1,432 subjects in set 1, 1,243 subjects in set 2.
- BP Dataset 26 PDLIM5 family-based association study. 5 markers, 1,938 subjects.
MULTIPLE — Studies BP0, 1, 19
- BP Dataset 17 genotypes from Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. 1,244 subjects.
MULTIPLE — Studies BP0, 1, 2
- BP Dataset 21 Common variants of G72 (DAOA), 2,490 subjects.
BP0 — NIMH BP Genetics Initiative
- BP Dataset 1 36 markers (4 on chromosome 13, 4 on chromosome 18, 3 on chromosome 21, 15 on chromosome 22, 6 on chromosome 4, and 4 on chromosome 5). 355 subjects.
- BP Dataset 13 Chromosome 5q31-34 / psychosis, GRIA1, 330 subjects.
- BP Dataset 14 240 markers on Chromosomes 1-6, 8-13, 22, X, Y. 427 subjects.
- BP Dataset 15 20 ANK3 markers on chromosomes 1-7, 10-13, 17. 2,519 subjects.
- BP Dataset 2 10 Markers on Chromosome 22. 487 subjects.
- BP Dataset 23 19 Cholinergic genes (93 SNPs) on 707 subjects. Includes family data
- BP Dataset 25 1,005 neurotransmitter markers (GRIA1, GRIN2D, QDPR, GRIN2C, QDPR, slc6a3). 1,195 subjects.
- BP Dataset 3 K274E Mutation in PAH, 11 subjects.
- BP Dataset 5 233 markers on Chromosomes 6, 12, 13, 18, 22. 2,127 subjects.
- BP Dataset 7 62 SNPs on Chromosomes 3, 4, 11, 12, 18, 19, 22 - circadian rhythm pathways. 832 subjects.
- BP Dataset 8 19 SNPs on Chromosomes 1, 2, 11, 12, 17 - circadian rhythm pathways. 1,435 subjects.
- BP Dataset 9 93 SNPs on Chromosomes 1, 2, 4, 7, 8, 10, 11, 15, 17, 20 - cholinergic pathways. 401 subjects.
Study 1 — A Collaborative Genomic Study of Bipolar Disorder
- BP Dataset 10 1004 SNPs on Chromosomes 1-13, 15-17, 19-23 family-based association study of neurotransmitter pathways, 735 subjects.
- BP Dataset 6 30 trace amine receptors markers, 987 subjects
Study 2 — Molecular Genetics of Bipolar Disorder
- BP Dataset 12 P14K2b on Chromosome 4 / CERK, SULT4, BRD1, all genes on Chromosome 22, 248 subjects
CAPS — Combined Analysis of Psychiatric Studies
- BP Dataset 32 For more information, visit the CAPS homepage.
- BP Dataset 32 - readme For more information, visit the CAPS homepage.
PGC — Psychiatric GWAS Consortium
- PGC-BP - data & documentation Introduction, results, plots, and genotype data. For more information about PGC, visit https://www.med.unc.edu/pgc.
- PGC-BP - imputation & dosage data Imputation & dosage data, separated due to file size (15.5 GB).
- PGC-BP - imputation & dosage data - ReadMe Case-control data on 7274 subjects. 7 cohorts available, some at NRGR. 3,803 Total Cases. Imputed Genotypes on 2.5M SNPs
MULTIPLE — Studies BP0, 1, 40
- BP Dataset 27 Custom Illumina iSelect chip containing 7,584 SNPs on Chromosomes 1-22, 214 subjects.
MULTIPLE — Studies STEP-BD (19), MGS (29)
- BP Dataset 16.01 STEP-BD data. Case-control. 2453 samples (955 cases). PLINK files available from Affymetrix 5.0 platform. Study 29 controls included in dataset.
- BP Dataset 28 720 markers on chromosomes 1-23. Controls from study 29. 832 subjects.
MULTIPLE — BP Dataset 11 (Pritzker)
- BP Dataset 11 Case-Control data on 1956 samples. PLINK, logR/BAF files from Illumina 550k platform available. Intensity files are shipped by request due to the large size of the files. To request shipment, please contact help@nrgr.on.spiceworks.com and reference your active access approval ID.
BP0 — NIMH BP Genetics Initiative
- BP Dataset 20 Full Genome Screen. 624 markers, 238 subjects in 48 families
- BP Dataset 4 Full Genome Screen. 4,332 subjects.
Study 49 — Genetics of Bipolar Disorder in Latino Populations
- BP Dataset 29 SNP Linkage Genotyping Data, 5,606 markers, 2,466 subjects.
Study 71 — Bipolar Endophenotypes in Population Isolates
- BP Dataset 31 Full Genome Screen, 1,054,197 SNPs, 838 subjects
BP0 — NIMH BP Genetics Initiative
Study 1 — A Collaborative Genomic Study of Bipolar Disorder
Study 2 — Molecular Genetics of Bipolar Disorder
Study 8 — Genetic Analysis of Bipolar Disorder
Study 19 — Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
Study 40 — Bipolar Genome Study (BiGS)
Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.
MULTIPLE — Studies BP0, 2
File B: This file includes DIGS info for all other sites in BP distribution 4.0. Data may be in DIGS version 1.0 or 2.0, but both versions have a core of variables in common.
Study 1 — A Collaborative Genomic Study of Bipolar Disorder
File A: This file is in the DIGS version 3 paradox file format for distribution 4.01 data. It includes data for a group of 9 sites (from study1, wave3 & 4). These files are totally different in format from earlier versions (variable names, etc). This is DIGS 3.0/B.
Study 8 — Genetic Analysis of Bipolar Disorder
File C: This file includes DIGS information for subjects in Study 8 added in BP Distribution 4.0. Data is in DIGS Version 2.0. Key variables are the same as in File B, but formats and variable lengths differ.
Study 40 — Bipolar Genome Study (BiGS)
File D: This file includes DIGS information for subjects in Study 40 added in BP Distribution 6.02. This is a new version of DIGS.
Study 48 — Genetic Linkage and Association in Bipolar Disorder / Amish Mennonite Bipolar Genetics Study (AmBiGen)
DIGS data for Study 48 (Part 1)/Sites 186-188 (PIs: McMahon, DePaulo, Gershon) were collected using DIGS Version 3.0
Study 49 — Genetics of Bipolar Disorder in Latino Populations
File E: This file includes DIGS information for subjects in Study 49 Version 2 added in BP Distribution 7.01. This is DIGS Version 2.0.
BP0 — NIMH BP Genetics Initiative
- Study 0 Extended Diagnosis File [text or excel]
- Study 0 Dx Confidence Harmonization Phen [text or excel]
Study 1 — A Collaborative Genomic Study of Bipolar Disorder
- Study 1 Extended Diagnosis File [text or excel]
- Study 1 Dx Confidence Harmonization Phen [text or excel]
Study 2 — Molecular Genetics of Bipolar Disorder
- Study 2 Extended Diagnosis File [text or excel]
- Study 2 Dx Confidence Harmonization Phen [text or excel]
Study 8 — Genetic Analysis of Bipolar Disorder
Study 19 — Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
- Overview of STEP-BD Longitudinal clinical trial of outpatient BP cases.
- Study 19 Extended Diagnosis File [text or excel]
- Study 19 Age Onset Range Phen [text or excel]
Study 40 — Bipolar Genome Study (BiGS)
Study 48 — Genetic Linkage and Association in Bipolar Disorder / Amish Mennonite Bipolar Genetics Study (AmBiGen)
- Study 48 Extended Diagnosis File [text or excel]
- Study 48 Dx Confidence Harmonization Phen [text or excel]
Study 49 — Genetics of Bipolar Disorder in Latino Populations
Study 55 — Adolescents at High Risk for Familial Bipolar Disorder
- Phenotypic Data Interview data includes Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS), Children's Global Assessment Scale (C-GAS), Home Environment Interview for Children (HEIC)
- Study 55 Extended Diagnosis File [text or excel]
Study 71 — Bipolar Endophenotypes in Population Isolates
- Phenotypic Data Data includes MRI results, and Temperament Evaluation of Memphis, Pisa, Paris, and San Diego (TEMPS), Weschler Abbreviated Scale of Intelligence (WASI), California Verbal Learning Test (CVLT), among other interviews.
- Study 71 Extended Diagnosis File [text or excel]
- Study 71 Dx Confidence Harmonization Phen [text or excel]
Study 75 — Lithium Use for Bipolar Disorder: A Randomized Controlled Effectiveness Trial (LiTMUS)
- Phenotypic Data LiTMUS - primary outcome measures include Clinical Global Impression Scale for Bipolar Disorder Severity (CGI-BP-S) and medical adjustments per month. MINI-PLUS used to dermine DSM-IV diagnoses.
Study 77 — International Cohort Collection for Bipolar Disorder (ICCBD)
Study 123 — Acute Psychotherapy for Bipolar II Depression
- Study 123 Extended Diagnosis File [text or excel]
- Study 123 Dx Confidence Harmonization Phen [text or excel]
Study 140 — Genome Sequencing in Extended Bipolar Pedigrees
Study 179 — Ultra High Field Strength MRI and MRS Study of Bipolar Disorder in Adolescents
Study 188 — Aging and Emotion Regulation Brain Circuitry in Bipolar Disorder
Study 19 — Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
Study 123 — Acute Psychotherapy for Bipolar II Depression
- Phenotypic Data Diagnostic data, including Hamilton Depression Rating Scale, and response to Interpersonal and Social Rhythm therapy.
Study 77 — International Cohort Collection for Bipolar Disorder (ICCBD)
- Phenotypic Data Diagnoses were reached using the OPCRIT system populated with DI-PAD data and supplemented by manual review of DI-PAD data as necessary.